July 9, 2026
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Published by Clinical Leader
Author: Kurt Mussina, CEO, Paradigm Clinical Research, and Co-Founder, Association of Multisite Research Corporations (AMRC)
In the second article of his Clinical Leader series, Kurt Mussina builds on the operating-model taxonomy introduced in Part 1 and examines how different clinical research site models perform in practice. The article compares freestanding research clinics, embedded private-practice research sites, investigator models, site networks, hospital-based models, and pure-play approaches, highlighting where each structure creates advantage and where it can introduce risk. The central question is whether a site model is built not just for reach, but for controlled, repeatable trial performance.
The article covers:
- The operational strengths of freestanding research clinics
- The patient-access advantages of embedded private-practice research sites
- The implications of employee PIs, contracted private-practice PIs, and mixed investigator models
- Why site networks and SMO-style models can create breadth without operating control
- Why hospital-heavy models may be mismatched for many commercial outpatient trials
- The strengths and limitations of pure-play site models
- Why model fit matters for sponsors, CROs, investors, and site operators
Read the full article in Clinical Leader: https://www.clinicalleader.com/doc/how-clinical-research-site-operating-models-perform-in-practice
About Paradigm Clinical Research
Paradigm Clinical Research is a clinical research site organization supporting phase I–IV programs across metabolic disease, dermatology, pulmonology, neurology, psychiatry, ophthalmology, and vaccines and infectious disease. Paradigm operates wholly owned clinical trial sites with centralized governance and infrastructure designed to minimize operational variability across sites, a common challenge in multi-site clinical trials.
In collaboration with more than 40 board-certified principal investigators, the company delivers expertly conducted clinical studies and access to diverse and specialty patient populations for sponsors and CRO partners. Additional information is available at www.paradigm-research.com.