July 8, 2026
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Published by Clinical Leader
Author: Kurt Mussina, CEO, Paradigm Clinical Research, and Co-Founder, Association of Multisite Research Corporations (AMRC)
In the first article of a three-part Clinical Leader series, Kurt Mussina examines why traditional measures of clinical research site strength — including site count, investigator lists, therapeutic area coverage, geography, and claimed patient access — do not fully explain performance. The article introduces operating model as a more meaningful lens for evaluating whether a site organization can turn reach into reliable execution, and it outlines a taxonomy for understanding the major site operating models in today’s clinical research landscape.
The article covers:
- Why “site” is an imprecise term in clinical research
- How operating model affects control, quality, recruitment, start-up, communication, and accountability
- A taxonomy of clinical research site operating models
- The distinction between legal ownership and operational integration
- Why “wholly owned” does not always mean fully integrated
- How de novo and acquisitive growth paths affect operating consistency
Read the full article at Clinical Leader: https://www.clinicalleader.com/doc/why-operating-model-is-the-next-competitive-frontier-in-clinical-research-site-strategy-part-one
About Paradigm Clinical Research
Paradigm Clinical Research is a clinical research site organization supporting phase I–IV programs across metabolic disease, dermatology, pulmonology, neurology, psychiatry, ophthalmology, and vaccines and infectious disease. Paradigm operates wholly owned clinical trial sites with centralized governance and infrastructure designed to minimize operational variability across sites, a common challenge in multi-site clinical trials.
In collaboration with more than 40 board-certified principal investigators, the company delivers expertly conducted clinical studies and access to diverse and specialty patient populations for sponsors and CRO partners. Additional information is available at www.paradigm-research.com.